Why excessive sleepiness may persist in OSA patients receiving adequate CPAP treatment.
نویسندگان
چکیده
phosphodiesterase-4 inhibitor BAY 19-8004 on lung function and airway inflammation in asthma and chronic obstructive pulmonary disease (COPD). Pulm Pharmacol Ther 2003; 16: 341–347. 5 Hatzelmann A, Morcillo EJ, Lungarella G, et al. The preclinical pharmacology of roflumilast – a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease. Pulm Pharmacol Ther 2010; 23: 235–256. 6 Grootendorst DC, Gauw SA, Verhoosel RM, et al. Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD. Thorax 2007; 62: 1081–1087. 7 Gamble E, Grootendorst DC, Brightling CE, et al. Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2003; 168: 976–982. 8 Homma S, Sakamoto T, Hegab AE, et al. Association of phosphodiesterase 4D gene polymorphisms with chronic obstructive pulmonary disease: relationship to interleukin 13 gene polymorphism. Int J Mol Med 2006; 18: 933–939. 9 Barber R, Baillie GS, Bergmann R, et al. Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers. Am J Physiol Lung Cell Mol Physiol 2004; 287: L332–L343.
منابع مشابه
Waking up to sleep-disordered breathing.
In 1997 Wright and colleagues published a systematic review on the health effects of obstructive sleep apnoea syndrome (OSA) and the effectiveness of treatment with continuous positive airway pressure (CPAP). They concluded that there was limited evidence of increased mortality or morbidity in patients with OSA, and that the evidence linking the condition to cardiovascular risk factors and moto...
متن کاملResidual sleepiness in patients with OSA on CPAP
PEPIN et al. [1] recently published a very interesting study of residual excessive sleepiness (RES) in 502 patients with obstructive sleep apnoea treated successfully with continuous positive airway pressure (CPAP). They concluded that a significant percentage (about 6–12%, depending on inclusion criteria) had RES. They concluded that, since about 230,000 French patients are on CPAP, a minimum ...
متن کاملResidual sleepiness in patients with OSA on CPAP.
PEPIN et al. [1] recently published a very interesting study of residual excessive sleepiness (RES) in 502 patients with obstructive sleep apnoea treated successfully with continuous positive airway pressure (CPAP). They concluded that a significant percentage (about 6–12%, depending on inclusion criteria) had RES. They concluded that, since about 230,000 French patients are on CPAP, a minimum ...
متن کاملFactors affecting CPAP acceptance in elderly patients with obstructive sleep apnea in Taiwan.
BACKGROUND The prevalence of obstructive sleep apnea (OSA) increases with age. Treatment often includes CPAP. CPAP adherence is correlated with disease severity and symptoms. We hypothesized that CPAP acceptance rates in elderly patients with OSA would be lower than in younger patients with OSA, and examined factors associated with CPAP acceptance. METHODS We reviewed the charts of 315 subjec...
متن کاملContinuous Positive Airway Pressure (cpap) Has Been Shown to Reduce Daytime Sleepiness in Patients with Obstructive Sleep Apnea
111 The Effect of CPAP on Neurobehavior in OSA—Antic et al CONTINUOUS POSITIVE AIRWAY PRESSURE (CPAP) HAS BEEN SHOWN TO REDUCE DAYTIME SLEEPINESS IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA (OSA) and is widely accepted as the most efficacious therapy for OSA. Patel and colleagues performed a meta-analysis showing that CPAP reduced the Epworth Sleepiness Scale (ESS) score an average of 2.9 points m...
متن کاملResidual Daytime Sleepiness in Obstructive Sleep Apnea After Continuous Positive Airway Pressure Optimization: Causes and Management.
Excessive daytime sleepiness (EDS) is common in obstructive sleep apnea (OSA), but it is also common in the general population. When sleepiness remains after continuous positive airway pressure (CPAP) treatment of OSA, comorbid conditions or permanent brain injury before CPAP therapy may be the cause of the residual sleepiness. There is currently no broad approach to treating residual EDS in pa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The European respiratory journal
دوره 39 1 شماره
صفحات -
تاریخ انتشار 2012